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US 5,321,010 AGranted
Proteins for inhibiting adhesion of platelets to collagen
AssigneeMerck & Co., Inc.
InventorsThomas M. Connolly, Michael Neeper, Lloyd Waxman
Life of this patent
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Abstract
The invention comprises proteinaceous substances isolated from crude Ornithodoros moubata extract which inhibit adhesion of platelets to collagen. These substances do not inhibit platelet adhesion to fibrinogen, and are therefore particularly useful for inhibiting adhesion of platelets to collagen when simultaneous inhibition of platelet adhesion to fibrinogen is undesired. They are particularly useful in the prevention, prophylaxis, therapy and treatment of thrombotic diseases.
Claims3
A substantially purified protein having the following amino acid composition:
- ______________________________________ Amino acid Residues/molecule ______________________________________ Asx 12.3 Thr 10.4 Ser 17.3 Glx 19.8 Gly 15.9 Ala 8.6 Cys 4.0 Val 9.0 Ile 3.7 Leu 9.0 Tyr 3.7 Phe 4.0 His 1.9 Lys 6.9 Arg 7.9 Pro 8.9 Trp 2.0 Met 1.3 ______________________________________
- having a molecular weight of about 15,600 which inhibits platelet adhesion to collagen and which does not inhibit platelet adhesion to fibrinogen or fibronectin, wherein residues/molecule is calculated based on amino acid composition analysis.
Dependencies are inferred from the claim text.