Process of making nadolol
AssigneeACIC (Canada) Inc.
InventorKhashayar Karimian
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Abstract
A process for making 5-(d-3-(tert-butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydro-1-cis-2,3 naphthalenediol of the formula ##STR1## by reacting ##STR2## in an essentially water free environment with (a) M'IO.sub.3 wherein M' represents a suitable ion for forming the salt. (b) I.sub.2 (iodine) (c) CH.sub.3 COO.sup.- M".sup.+ wherein M" represents a suitable ion for forming the salt (d) glacial acetic acid and (e) ROH/M'"OH where R is alkyl and M'" is a suitable metal ion.
Claims13
A process for making 5-{d-3-(tert-butylamino)-2-hydroxypropoxy}-1,2,3,4-tetrahydro-1-cis-2,3 naphthalenediol of the formula ##STR15## by reacting ##STR16## in an essentially water free environment with (a) M'IO.sub.3 wherein M' represents a suitable ion for forming the salt.
- (b) I.sub.2 (iodine)
- (c) CH.sub.3 COO.sup.- M".sup.+ wherein M" represents a suitable ion for forming the salt
- (d) glacial acetic acid and
- (e) ROH/M"'OH where R is alkyl and M"' is a suitable metal ion.
A process for directly making the cis-isomer of Nadolol, the process comprising carrying out the following steps:
- ##STR25##
A process for directly making the cis-isomer Nadolol, the process comprising carrying out the following steps:
- ##STR26##
Dependencies are inferred from the claim text.