Naphthalene derivatives

A naphthalene derivative represented by the following general formula or a pharmacologically acceptable salt thereof:

• ##STR144## wherein R.sup.1 stands for a hydrogen atom or a lower alkyl, acyl or arylalkyl group;
• R.sup.2 stands for a hydrogen atom or a lower alkyl, lower alkoxy, cycloalkoxy or acyl group;
• R.sup.3 stands for:
• the formula:
• ##STR145## wherein R.sup.10 and R.sup.11 may be the same or different from each other and each stands for a hydrogen atom, a hydroxyl, lower alkyl, lower alkoxy, aryl, heteroaryl group or a group represented by the formula:
• --(CH.sub.2).sub.q --COOH (wherein q is an integer of 1 to 2), or alternatively R.sup.10 and R.sup.11 may form a ring which may contain a nitrogen, oxygen or sulfur atom together with the nitrogen atom to which R.sup.10 and R.sup.11 are bonded);
• Z stands for a group represented by the formula:
• ##STR146## (wherein R.sup.5 and R.sup.6 may be the same or different from each other and each stands for a hydrogen atom or a lower alkyl, alkenylalkyl, alkynylalkyl or aryl group, an arylalkyl group, the aryl group of which may be substituted, a halogen atom or a heteroarylalkyl, cycloalkyl, cycloalkylalkyl, lower alkoxyalkyl, heterocycloalkyl or cyano group, or alternatively R.sup.5 and R.sup.6 may form a ring together with the carbon atom to which R.sup.5 and R.sup.6 are bonded), a group represented by the formula:
• .dbd.N--OR.sup.7 (wherein R.sup.7 stands for a lower alkyl group) or an oxygen atom;
• Y stands for a group represented by the formula:
• --(CH.sub.2).sub.n -- (wherein n is 0 or an integer of 1 to 2) or a group represented by the formula:
• ##STR147## (wherein R.sup.8 and R.sup.9 may be the same or different from each other and each stands for a lower alkyl group);
• and
• R.sup.4 stands for a hydrogen atom, a lower alkyl group or a group represented by the formula:
• ##STR148## (wherein p is 0 or an integer of 1 to 3 and R.sup.12 stands for a hydrogen or halogen atom or a lower alkyl or lower alkoxy group).