Fibrin sealant delivery kit
AssigneeCryolife, Inc.
InventorsBrenda S. Morse, A. Denise Turner, Robert T. McNally
Life of this patent
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Abstract
The present invention relates to a method for the formulation of fibrin sealant in a single delivery system. The method involves mixing a fibrinogen/Factor XIII precipitate solution with thrombin under conditions such that thrombin clotting activity is inhibited and said mixture is applied to a body site under conditions which activate the thrombin to convert fibrinogen into fibrin sealant. A single device, syringe or container, can be used to apply the fibrin sealant formulation.
Claims8
An applicator for use in the preparation of a fibrin sealant comprising a container means and an outlet means operably connected thereto, said container means having disposed therewithin a solution consisting essentially of fibrinogen, Factor XIII, mature thrombin and an agent that inhibits the clotting activity of said mature thrombin.
A kit for use in the preparation of a fibrin sealant comprising an applicator that comprises:
- i) a container means having disposed therewithin a solution comprising fibrinogen, Factor XIII, mature thrombin and a calcium chelator;
- and
- ii) an outlet means operably connected to said container means, wherein said outlet means has a calcium salt disposed therewithin.
A kit for use in the preparation of a fibrin sealant comprising an applicator that comprises:
- i) a container means having disposed therewithin a solution comprising fibrinogen, Factor XIII and mature thrombin, wherein said solution has a pH of less than about 5.5;
- and
- ii) an outlet means operably connected to said container means, wherein said outlet means has a neutralizing buffer salt disposed therewithin.
A kit for use in the preparation of a fibrin sealant comprising an applicator that comprises:
- i) a container means having disposed therewithin a solution comprising fibrinogen, Factor XIII, mature thrombin and a photosensitive inhibitor of thrombin clotting activity;
- and
- ii) an outlet means operably connected to said container means,
- wherein said container means and said outlet means are constructed of a material that does not transmit light of a wavelength to which said inhibitor is sensitive.
Dependencies are inferred from the claim text.