7-((su bstituted)amino)-8((substituted)carbonyl)-methylamino-1-oxaspiro(4,5)deca nes useful in Parkinson's disease, dystonia, and other movement disorders
AssigneeWarner-Lambert Company
InventorsAlexander McKnight, Geoffrey N. Wodruff
Life of this patent
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Abstract
Methods for using substituted phenoxy-, 1-, and 2-naphthalenyloxy-, indenyl-, indolyl-, benzo[b] furanyl-, and benzo[b]thienylcarboxamides of 7,8-(substituted-diamino)-1-oxaspiro[4.5]decanes as agents for alleviating the symptoms of Parkinson's disease, dystonia, and other movement disorders are disclosed. Pharmaceutical compositions employing the compounds are also disclosed.
Claims6
A method for treating Parkinson's disease which comprises administering to a patient in need of said treatment a therapeutically effective amount of a compound in unit dosage form of formula ##STR13## or a pharmaceutically acceptable salt thereof wherein n is an integer of from one to six;
- either of X or Y is oxygen and the other is --CH.sub.2 --;
- R.sub.1 is selected from
- a) ##STR14## wherein R.sub.4 and R.sub.5 are independently hydrogen, fluorine, chlorine, bromine, nitro, trifluoromethyl, alkyl of from one to six carbon atoms, alkoxy of from one to six carbon atoms, or aryl;
- b) 3,4,5-trimethylphenoxy;
- c) ##STR15## wherein R.sub.6 is hydrogen, fluorine, chlorine, alkyl of from one to six carbon atoms, or aryl;
- Z is --CH.sub.2 --, --O--, --S--, or --NR.sub.7 --where R.sub.7 is hydrogen, alkanoyl of from one to six carbon atoms, or alkyl of from one to six carbon atoms;
- d) ##STR16## wherein R.sub.8 and R.sub.9 are independently hydrogen, fluorine, bromine, alkyl of from one to six carbon atoms, or alkoxy of from one to four carbon atoms;
- or
- e) ##STR17## wherein R.sub.8 and R.sub.9 are as defined above;
- where R.sub.2 and R.sub.3 taken together with the nitrogen atom to which they are attached, form a pyrrolidinyl ring.
A method for treating dystonia which comprises administering to a patient in need of said treatment a therapeutically effective amount of a compound in unit dosage form of formula ##STR18## or a pharmaceutically acceptable salt thereof, wherein n is an integer of from one to six;
- either of X or Y is oxygen and the other is --CH.sub.2 --;
- R.sub.1 is selected from
- a) ##STR19## where R.sub.4 and R.sub.5 are independently hydrogen, fluorine, chlorine, bromine, nitro, trifluoromethyl, alkyl of from one to six carbon atoms, alkoxy of from one to six carbon atoms, or aryl;
- b) 3,4,5-trimethylphenoxy;
- c) ##STR20## wherein R.sub.6 is hydrogen, fluorine, chlorine, alkyl of from one to six carbon atoms, or aryl;
- Z is --CH.sub.2 --, --O--, --S--, or --NR.sub.7 --wherein R.sub.7 is hydrogen, alkanoyl of from one to six carbon atoms, or alkyl of from one to six carbon atoms;
- d) ##STR21## wherein R.sub.8 and R.sub.9 are independently hydrogen, fluorine, bromine, alkyl of from one to six carbon atoms, or alkoxy of from one to four carbon atoms;
- or
- e) ##STR22## where R.sub.8 and R.sub.9 are as defined above;
- where R.sub.2 and R.sub.3 taken together with the nitrogen atom to which they are attached, form a pyrrolidinyl ring.
Dependencies are inferred from the claim text.