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US 5,317,025 AGranted
Piperidinylthioindole derivatives, their methods of preparation and pharmaceutical compositions in which they are present, useful especially as analgesics
AssigneeLaboratoires USPA
InventorsNicole Bru-Magniez, Dominique Potin, Jean-Marie Teulon
Life of this patent
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Abstract
The present invention relates to the derivatives of the formula ##STR1## and their addition salts, and to their use in therapeutics, especially as drugs having analgesic properties.
Claims11
A piperidinylthioindole compound of formula (I):
- ##STR50## in which:
- X.sub.1 and X.sub.2 are independently:
- a hydrogen atom;
- a halogen atom;
- a lower alkyl radical having 1 to 6 carbon atoms;
- a trifluoromethyl group;
- or
- a lower O-alkyl radical having 1 to 6 carbon atoms;
- and can he located in the 4-, 5-, 6- or 7-position of the indole ring,
- R.sub.1 is:
- a hydrogen atom;
- a lower alkyl radical having 1 to 6 carbon atoms;
- a radical --(CH.sub.2).sub.n -phenyl;
- or
- a radical --(CH.sub.2).sub.n -pyrrole;
- in which n is an integer from 0 to 4,
- R.sub.2 is:
- a hydrogen atom;
- a lower alkyl radical having 1 to 6 carbon atoms;
- or
- a phenyl radical which is unsubstituted or substituted by a halogen atom,
- R.sub.3 is:
- a hydrogen atom;
- a lower alkyl radical having 1 to 6 carbon atoms;
- or
- a radical --(CH.sub.2).sub.n -phenyl in which the phenyl is unsubstituted or substituted by a halogen atom, n being an integer from 0 to 4, and
- p is an integer from0 to 2, or a pharmaceutically acceptable addition salt thereof.
24 more elements
Dependencies are inferred from the claim text.