Benzodiazepines and compositions for treating anxiety and panic disorders, and idiopathic and psychomotor epilepsy
OwnerArmin Walser, Alessandro Guidotti +1inventors
InventorsArmin Walser, Alessandro Guidotti, Erminio Costa
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Abstract
The present invention is directed to imidazo[1,5-a][1,4]benzodiazepine-3-carboxamide compounds of the formula: ##STR1## wherein R is hydrogen, C.sub.3 CH.sub.2 --, CH.sub.2 .dbd.CHCH.sub.2 --, (CH.sub.3).sub.2 CH--, CH.sub.3 CH.sub.2 CH.sub.2 --, or ##STR2## or a pharmaceutically acceptable salt thereof. These compounds and their pharmaceutically acceptable salts possess anti-anxiety and anti-epileptic activity.
Claims24
A compound of the formula:
- ##STR8## wherein R is hydrogen, CH.sub.3 CH.sub.2 --, CH.sub.2 .dbd.CH--CH.sub.2 --, (CH.sub.3).sub.2 CH--, CH.sub.3 CH.sub.2 CH.sub.2 -- or ##STR9## or a pharmaceutically acceptable salt thereof.
A method of treating panic disorders in a host comprising administering to the host in need of such treatment an effective antipanic amount of a compound of the formula:
- ##STR10## wherein R is hydrogen, CH.sub.3 CH.sub.2 --, CH.sub.2 .dbd.CHCH.sub.2 --, (CH.sub.3).sub.2 CH--, CH.sub.3 CH.sub.2 CH.sub.2 --, or ##STR11## or a pharmaceutically acceptable salt thereof.
A method of treating epileptic disorders in a host comprising administering to a host in need of such treatment, an effective antiepileptic amount of a compound of the formula:
- ##STR12## wherein R is hydrogen, CH.sub.3 CH.sub.2 --, CH.sub.2 .dbd.CHCH.sub.2 --, (CH.sub.3).sub.2 CH--, CH.sub.3 CH.sub.2 CH.sub.2 --, or ##STR13## or a pharmaceutically acceptable salt thereof.
The compound 6-(2-bromophenyl)-N-[(cyclopropyl)methyl]-8-fluoro-4H-imidazo[1,5-a][1,4]b enzodiazepine-3-carboxamide;
- or a pharmaceutically acceptable salt thereof.
The compound 6-(2-bromophenyl)-8-fluoro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxam ide;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.