Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives
AssigneeScripps Clinic and Research Foundation
InventorsMichael G. Goodman, William O. Weigle
Life of this patent
Estimating the term…
Abstract
Compositions and methods for their use in modulating animal cellular responses are disclosed. The compositions include as an active agent an effective amount of an 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain. The composition includes a diluent amount of a physiologically tolerable carrier. The guanine derivative is free of electrically charged functionality, while the 8-substituent has an electron withdrawing inductive effect greater than that of hydrogen and contains fewer than about 15 atoms. Animal cellular responses are modulated by contacting the cells with a composition of this invention.
Claims9
A method of inducing interleukin-1-like activity in macrophages comprising contacting said macrophages with a composition including as an active ingredient an effective amount of 8-substituted guanine derivative bonded 9-1' to an aldose having 5 or 6 carbon atoms in the aldose chain, said guanine derivative being free of electrically charged functionality, and said 8-substituent having an electron withdrawing effect greater than that of hydrogen and containing fewer than about 15 atoms, together with a diluent amount of a physiologically tolerable carrier.
Dependencies are inferred from the claim text.