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US 5,316,680 AGranted
Multimodal chromatographic separation media and process for using same
AssigneeCornell Research Foundation, Inc.
InventorsJean M. J. Frechet, Frantisek Svec, Vladimir Smigol
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Abstract
A process for carrying out in a consecutive fashion different modes of chromatographic separation in a liquid chromatography column using a single separation medium is disclosed. Separation media for use in such multimodal separations are also disclosed.
Claims21
A process for separating different molecules from a sample containing at least two different molecules comprising:
- (1) adding the sample to a chromatographic column containing a separation medium, said separation medium comprising a porous material having at least two different ranges of pore size with each pore size range containing a different surface group having a different functionality as compared to the surface group in the other pore size range,
- (2) using the different surface groups within the different pore size ranges, to separate the different molecules from each other and the sample, said separation being carried out using at least 2 modes of chromatographic separation in a consecutive manner so as to separate during each mode of chromatographic separation a different molecule from the sample.
Dependencies are inferred from the claim text.