Back to results
US 5,315,015 AGranted
Compounds having improved fluorescence in fluorescence polarization immunoassays and immunoassays utilizing same
AssigneeHoffmann-La Roche Inc.
InventorsRaymond A. Hui, Kathryn S. Schwenzer
Life of this patent
Estimating the term…
Abstract
Compounds of the formula ##STR1## wherein F is a fluorescing compound; Y is --NH-- or a single covalent bond; Z is a straight or branched alkylene chain of 2 to 10 carbon atoms which is substituted by at least one hydrophilic group; Q is oxygen or sulfur; and X is a ligand-analog, the ligand-analog capable of being recognized by an antibody specific to the corresponding ligand. These compounds have improved properties in fluorescence polarization immunoassays by possessing either a better intensity and/or a larger span.
Claims13
A compound of the formula:
- ##STR12## wherein F is a fluorescent group;
- Y is --NH-- or a single covalent bond;
- Z is straight or branched alkylene chain of two to ten carbon atoms which is substituted with at least one hydrophilic group;
- Q is oxygen or sulfur;
- and X is a ligand-analog capable of being recognized by an antibody specific to the corresponding ligand.
2 more elements
Dependencies are inferred from the claim text.