Loading patent…
AssigneePermeable Technologies, Inc.
InventorsWaifong L. Anton, Henry D. Coleman, Mohammed I. Ali, Lester Weintraub
Estimating the term…
The present invention relates to novel copolymers and contact lenses made from these copolymers comprising preformed silicone-containing acrylic star polymers, graft copolymers and macromonomers, preparation of these contact lenses and a therapeutic method for treating patients with visual impairment. Described is a composition comprising at least about 10% by weight of a preformed silicone-containing acrylic copolymer and no more than about 90% by weight of a matrix formed from the random polymerization of a mixture of monomers. The mixture of monomers comprises at least one hydrophilic monomer and at least about 5% by weight of a polysiloxanylalkylester of an alpha, beta unsaturated acid and optionally, monomers selected from the group consisting of esters of alpha, beta-unsaturated acids and crosslinking monomers. The preformed silicone-containing acrylic copolymer is preferably copolymerized throughout the matrix. The final compositions are hydrated to a final water content of at least about 10% by weight.
A composition comprising at least about 20% by weight of at least one linear diblock macromonomer comprising about 20% to about 70% by weight of at least one hydrophilic block, said hydrophilic block consisting essentially of monomeric units derived from at least one hydrophilic acrylic monomer and about 30% to about 80% by weight of at least one hydrophobic, permeable block, said hydrophobic block comprising about 80% to about 100% by weight of monomeric units derived from at least one silicone acrylate, said composition comprising no more than about 75% by weight of a matrix formed from the random polymerization of a mixture of monomers, said composition before said polymerization including about 5% to about 45% by weight of at least one silicone acrylate, said mixture of monomers including an amount of hydrophilic monomer effective to provide a final composition which upon hydration comprises at least about 10% by weight water, said composition after hydration being clear and wettable, said macromonomer being copolymerized throughout said matrix.
A composition comprising about 20% to about 60% by weight of at least one linear diblock macromonomer and about 35% to about 75% by weight of a matrix formed from the random polymerization of a mixture of monomers in combination with said macromonomer, said macromonomer comprising about 20% to about 70% by weight of at least one hydrophilic block, said hydrophilic block comprising about 80% to about 100% by weight of monomeric units derived from at least one hydrophilic acrylic monomer and about 30% to about 80% by weight of at least one hydrophobic, permeable block, said hydrophobic block comprising about 80% to about 100% by weight silicone acrylate monomeric units, said mixture of monomers comprising at least one hydrophilic monomer in an amount effective to provide a composition which comprises at least about 23% to about 65% by weight water after hydration, said composition also comprising about 5% to about 45% by weight of monomeric silicone acrylate before said polymerization, said composition after hydration being clear and wettable, said macromonomer being copolymerized throughout said matrix.
Dependencies are inferred from the claim text.