Benzimidazole compounds useful as calcium channel blockers
AssigneeNeuroSearch A/S
InventorsOskar Axelsson, Mikkel Thaning, Peter Moldt
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Abstract
The present invention discloses compounds of the formula ##STR1## wherein R' and R" independently of each other are hydrogen or alkyl, or R' and R" together form a 3 to 6 membered alkylene chain; n is 1 or 2; R.sup.1 is phenyl which may be substituted one or more times with halogen, CF.sub.3, alkoxy, alkyl, or amino; and R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently of each other are hydrogen, halogen, amino, CF.sub.3, alkyl or alkoxy; or a pharmaceutically-acceptable addition salt thereof. The compounds are useful as pharmaceuticals, for example, in the treatment of ischemia, anoxia, migraine and psychosis.
Claims7
A method of treating a disorder, which is responsive to the partial or complete blockade of calcium channels of the central nervous system, of a mammal, including a human, which comprises administering to a mammal in need thereof a therapeutically-effective amount of a compound selected from those having the formula:
- ##STR9## wherein R' and R" independently of each other are hydrogen or alkyl, or R' and R" together form a 3 to 6 membered alkylene chain;
- n is 1 or 2;
- R.sup.1 is phenyl which may be substituted one or more times with halogen, CF.sub.3, alkoxy, alkyl, or amino;
- and
- R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently of each other are hydrogen, halogen, amino, CF.sub.3, alkyl or alkoxy;
- or a pharmaceutically-acceptable addition salt thereof.
A method of preventing degenerative changes connected with anoxia, ischemia, migraine, and epilepsia, which comprises administering to a patient in need thereof a therapeutically-effective amount of a compound selected from those having the formula:
- ##STR10## wherein R' and R" independently of each other are hydrogen or alkyl, or R' and R" together form a 3 to 6 membered alkylene chain;
- n is 1 or 2;
- R.sup.1 is phenyl which may be substituted one or more times with halogen, CF.sub.3, alkoxy, alkyl, or amino;
- and
- R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently of each other are hydrogen, halogen, amino, CF.sub.3, alkyl or alkoxy;
- or a pharmaceutically-acceptable addition salt thereof.
Dependencies are inferred from the claim text.