1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents
AssigneeWarner-Lambert Company
InventorsBradley W. Caprathe, Dennis M. Downing, Juan C. Jaen, Stephen J. Johnson, William J. Smith, III, Lawrence D. Wise, Jonathan Wright, David J. Wustrow
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Abstract
1,3-Substituted cycloalkenes and cycloalkanes are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.
Claims7
A compound of Formula I
- Z--CH.sub.2 --Y I
- wherein
- Z is ##STR41## wherein R is aryl, 2-, 3-, or 4-pyridinyl or 2-, 3-, or 4-pyridinyl substituted by lower alkyl, lower alkoxy, hydroxy, or halogen, and
- m is an integer of 1, 2, or 3, ##STR42## wherein R and m are as defined above, ##STR43## wherein R and m are as defined above, ##STR44## wherein R is as defined above;
- Y is ##STR45## whrein R is as defined above;
- and corresponding isomers thereof;
- or a pharmaceutically acceptable acid addition salt thereof.
A compound having the name (+)-1,2,3,6-Tetrahydro-4-phenyl-1-[(3-phenyl-3-cyclohexen-1-yl)methyl]pyri dine.
Dependencies are inferred from the claim text.