N-substituted lactams useful as cholecystokinin antagonists

A compound of the formula ##STR56## and isomers thereof;

• or a pharmaceutically acceptable acid or base addition salt thereof:
• wherein
• Ar is aryl;
• substituted aryl which can be substituted one or more by alkyl of 1 to 6 carbon atoms, alkoxy wherein the alkyl is 1 to 6 carbon atoms, trifluoromethyl, halogen, amino, alkyl or dialkyl substituted amino wherein the alkyl is 1 to 6 carbon atoms, fused bicyclic aromatic hydrocarbon radical having 9 or 10 carbon atoms;
• substituted fused bicyclic aromatic hydrocarbon radical having 9 or 10 carbon atoms which can be substituted one or more by alkyl of 1 to 6 carbon atoms, halogen, trifluoromethyl, amino, alkyl or dialkyl substituted amino wherein the alkyl is 1 to 6 carbon atoms, or alkoxy wherein the alkyl is 1 to 6 carbon atoms;
• R is alkyl having 1 to 8 carbon atoms wherein one of the carbon atoms may be replaced by oxygen;
• aryl;
• substituted aryl which can be substituted one or more by halogen, alkyl having 1 to 6 carbon atoms, alkoxy wherein the alkyl is 1 to 6 carbon atoms, amino, alkyl or dialkyl substituted amino wherein the alkyl is 1 to 6 carbon atoms, trifluoromethyl, or methylene dioxy;
• aralkyl wherein the alkyl is 1 to 8 carbon atoms;
• substituted aralkyl wherein the alkyl is 1 to 8 carbon atoms and the substituent or substituents are selected from the group consisting of halogen, alkyl having 1 to 6 carbon atoms, alkoxy wherein the alkyl is 1 to 6 carbon atoms, amino, alkyl or dialkyl substituted amino wherein the alkyl is 1 to 6 carbon atoms, trifluoromethyl, or methylene dioxy;
• X is a direct bond or a substituent selected from the group consisting of NH, oxygen or alkylene having 1 to 3 carbon atoms;
• n is 1;
• R.sub.1 and R.sub.1 ' are each independently hydrogen or alkyl having 1 to 4 carbon atoms;
• m is an integer from 0 to 3;
• R.sub.3 is NR.sub.8 R.sub.9 which together form a five to seven membered ring wherein R.sub.8 and R.sub.9 together represent an alkylene group having four to six carbon atoms and one of the carbon atoms may be optionally replaced by oxygen, nitrogen or NR.sub.10 wherein R.sub.10 represents hydrogen, or alkyl having 1 to 6 carbon atoms or aralkyl wherein the alkyl is 1 to 6 carbon atoms;
• R.sub.4 is hydrogen or alkyl having 1 to 4 carbon atoms;
• Y is C.dbd.O or SO.sub.2.

A compound of the formula ##STR58## and isomers thereof;

• or a pharmaceutically acceptable acid or base addition salt thereof:
• wherein
• Ar is aryl;
• substituted aryl which can be substituted one or more by alkyl of 1 to 6 carbon atoms, alkoxy wherein the alkyl is 1 to 6 carbon atoms, trifluoromethyl, halogen, amino, alkyl or dialkyl substituted amino wherein the alkyl is 1 to 6 carbon atoms, fused bicyclic aromatic hydrocarbon radical having 9 or 10 carbon atoms;
• substituted fused bicyclic aromatic hydrocarbon radical having 9 or 10 carbon atoms which can be substituted one or more by alkyl of 1 to 6 carbon atoms, halogen, trifluoromethyl, amino, alkyl or dialkyl substituted amino wherein the alkyl is 1 to 6 carbon atoms, or alkoxy wherein the alkyl is 1 to 6 carbon atoms;
• R is alkyl having 1 to 8 carbon atoms wherein one of the carbon atoms may be replaced by oxygen;
• aryl;
• substituted aryl which can be substituted one or more by halogen, alkyl having 1 to 6 carbon atoms, alkoxy wherein the alkyl is 1 to 6 carbon atoms, amino, alkyl or dialkyl substituted amino wherein the alkyl is 1 to 6 carbon atoms, trifluoromethyl, or methylene dioxy;
• aralkyl wherein the alkyl is 1 to 8 carbon atoms;
• substituted aralkyl wherein the alkyl is 1 to 8 carbon atoms and the substituent or substituents are selected from the group consisting of halogen, alkyl having 1 to 6 carbon atoms, alkoxy wherein the alkyl is 1 to 6 carbon atoms, amino, alkyl or dialkyl substituted amino wherein the alkyl is 1 to 6 carbon atoms, trifluoromethyl, or methylene dioxy;
• X is a direct bond or a substituent selected from the group consisting of NH, oxygen or alkylene having 1 to 3 carbon atoms.