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US 5,314,885 AGranted
Cyclic benzylamino, benzylamido, and benzylimido antipsychotic agents
AssigneeMcNeilab, Inc.
InventorsMalcolm K. Scott, Allen B. Reitz, Cynthia A. Maryanoff, Frank J. Villani, Jr.
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Abstract
Compounds of the general formula I ##STR1## are disclosed as novel antipsychotic agents. Pharmaceutical compositions and methods of treating convulsions employing such compounds of formula I are also disclosed.
Claims16
A compound of the formula I:
- ##STR6## wherein A is N
- Ar is aryl or substituted aryl;
- wherein the substituted aryl is independently substituted with one or more of C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.10 cycloalkyl, C.sub.1 -C.sub.8 hydroxyalkyl, C.sub.1 -C.sub.8 alkoxy, aryloxy hydroxyl, trifluoromethyl, trifluoromethoxy, cyano, C.sub.1 -C.sub.8 alkylthio, halogen, nitro, C.sub.1 -C.sub.8 haloalkyl, amino or C.sub.1 -C.sub.8 mono- or dialkylamino;
- Z is piperidinyl or a pharmaceutically acceptable salt thereof.
1 more element
Dependencies are inferred from the claim text.