2-pyrimidinyl-1-piperazine derivatives processes for their preparation and medicaments containing them
AssigneeTroponwerke GmbH & Co. KG
InventorsPeter-Rudolf Seidel, Harald Horstmann, Jorg Traber, Wolfgang Dompert, Thomas Glaser, Teunis Schuurman
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Abstract
The invention relates to substituted 2-pyrimidinyl-1-piperazine derivatives defined herein by formula (I), processes for their manufacture, compositions containing said substituted 2-pyrimidinyl-1-piperazine derivatives as active materials and the use of said compounds and compositions as agents effecting the central nervous system. Also included in the invention are intermediates of formula (VIII) for making the active formula (I) compounds.
Claims6
A compound of the formula ##STR131## in which R.sup.1 represents iodine, chlorine, trifluoromethyl, phenyl, 3,4-dimethoxyphenyl, 4-methoxyphenyl, 4-chlorophenyl, 3-trifluoromethylphenyl, 2-chloro-6-fluorophenyl or 3-indolyl;
- and
- R.sup.8 represents methoxycarbonyl, ethoxycarbonyl, n-propoxycarbonyl, i-propoxycarbonyl, butoxycarbonyl or phenoxycarbonyl.
A compound of the formula:
- ##STR132## in which R.sup.1 represents fluorine;
- and
- R.sup.8 represents methoxycarbonyl, n-propoxycarbonyl, i-propoxycarbonyl, butoxycarbonyl or phenoxycarbonyl.
Dependencies are inferred from the claim text.