High molecular mass N,O-sulphated heparosans, process for their preparation and the pharmaceutical compositions which contain them
AssigneeElf Sanofi
InventorsJean-Claude Lormeau, Bruno Chevallier, Marc L. V. Salome
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Abstract
The subject of the invention is new high molecular mass N,O-sulphated heparosans consisting of chains or of a mixture of chains having a molecular mass of between 1.5.times.10.sup.4 and 4.0.times.10.sup.6 D, characterised by a repeating disaccharide structure of formula I: ##STR1## in which E represents, in 0 to 80% of the disaccharide units of the said N,O-sulphated heparosan, an acetyl group and, in the remaining disaccharide units, a sulphate group and optionally a hydrogen atom, G represents a hydrogen atom and a sulphate group, and the pharmaceutically acceptable salts of the said N,O-sulphated heparosans.
Claims13
N,O-sulphated heparosans of chains or a mixture of chains of molecular mass between 1.5.times.10.sup.4 and 4.0.times.10.sup.6 Da, the molecular mass being determined by exclusion HPLC, which comprise repeated disaccharide units of formula I:
- ##STR11## in which:
- E represents an acetyl group in 0 to 80% of the disaccharide units, and a sulphate group or a hydrogen atom in the remaining disaccharide units,
- G represents a hydrogen atom or a sulphate group, or pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.