Method for treating swine dysentery with the derivatives of the antibiotic A82810
AssigneeEli Lilly and Company
InventorsRobert L. Hamill, Raymond C. Yao
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Abstract
New polyether antibiotic A82810, its acyl and alkyl ester, acyl ester and urethane derivatives, and salts thereof, are useful antibacterial and anticoccidial agents and increase feed-utilization efficiency in animals. Methods of making A82810 by culture of Actinomodura fibrosa sp. nov. NRRL 18348 and synergistic compositions of the A82810 compounds with nicarbazin, 4,4'-dinitrocarbanilide, certain napthalenamine and benzenamine compounds and metichlorpindol are also provided.
Claims1
A method for treating swine dysentery which comprises administering to swine suffering from or exposed to swine dysentery an effective amount of a compound of the formula ##STR5## wherein R is --CONHR.sub.1 and R.sub.1 is alkyl, aryl, alkyl-aryl, arylalkyl, haloaryl, nitroaryl, haloaryl-alkyl, alkoxyaryl, aryloxyaryl, arylcycloalkyl, acylaryl and cycloalkyl;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.