Glucan sulfate, stabilized fibroblast growth factor composition
AssigneeTakeda Chemical Industries, Ltd.
InventorsKoichi Kato, Kenji Kawahara, Tomoko Kajio
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Abstract
Fibroblast growth factor (FGF) or a mutein of FGF is stabilized by bringing FGF or a mutein of FGF into contact with a glucan sulfate in an aqueous medium. Thus obtained composition comprising (a) FGF or a mutein of FGF and (b) a glucan sulfate is stabilized, so that it can be advantageously administered to warm-blooded animals.
Claims15
A stabilized composition which comprises fibroblast growth factor (FGF) or a mutein consisting of a deletion mutein of FGF and a substitution mutein of FGF which exhibits pharmacological or physiological activities similar to those of FGF and a stabilizing amount of a glucan sulfate. PG,36
Dependencies are inferred from the claim text.