Immobilized hydrophobically-modified antibodies
AssigneeUniversity of New Mexico
InventorsWilliam L. Anderson, Dennis Otero
Life of this patent
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Abstract
The invention comprises stable, antigen-sensitive surfaces containing immobilized antibody modified with a polyethylene glycol spacer arm including a terminal hydrophobic moiety. The surfaces are generally useful in immunoassay procedures, especially microgravimetric assays such as those employing antibody immobilized on piezoelectric crystal surfaces.
Claims24
A protein modified with a hydrophobic moiety attached to the protein by a spacer comprising a water-soluble polymer, directly adsorbed onto an unprimed microporous mineral body surface.
A method for preparing an immunoreactive surface, comprising coating an unprimed microporous mineral body surface with an antigen or antibody modified with a hydrophobic moiety attached to the antigen or antibody by a spacer comprising a water-soluble polymer by drying the modified antigen or antibody onto the unprimed surface.
Dependencies are inferred from the claim text.