Method for producing an angiotensin converting enzyme inhibitor-containing composition
AssigneeNippon Gohsei Kagaku Kogyo Kabushiki Kaisha
InventorsMasaaki Yoshikawa, Keiichi Yokoyama, Masayasu Hasegawa, Ryouichi Yasumoto, Hiroyuki Fujita
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Abstract
A method of producing an angiotensin converting enzyme inhibitor-containing composition, which is of value as an antihypertensive agent or diet, from natural resources. According to the method, proteins are hydrolyzed with a protease elaborated by a microorganism of the genus Bacillus, Aspergillus or Rhizopus or a protease of papaya origin.
Claims5
A method of producing an angiotensin converting enzyme inhibitor peptide composition comprising Ile-Trp-His-His-Thr, Ala-Leu-Pro-His-Ala and Ile-Lys-Trp, said composition having an IC.sub.50 value of 110 .mu.g/ml or less, which comprises forming a solution by hydrolyzing dried bonito protein with water in the presence of a protease derived from a microorganism of the genus Bacillus, Aspergillus or Rhizopus, or a protease of papaya origin, and recovering the solution containing the peptide composition.
Dependencies are inferred from the claim text.