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US 5,314,697 AGranted
Stable extended release oral dosage composition comprising loratadine and pseudoephedrine
AssigneeSchering Corporation
InventorsHenry K. Kwan, Stephen M. Liebowitz
Life of this patent
Estimating the term…
Abstract
A film-coated extended release oral dosage composition containing the nasal decongestant pseudoephedrine sulfate in a unique polymer matrix core and a film-coating on such core containing the non-sedating antihistamine, loratadine, and use of the said composition for treating patients showing the signs and symptoms associated with upper respiratory diseases and nasal congestion are disclosed.
Claims7
A film-coated extended release oral dosage composition comprising:
- a. a matrix core comprising:
- ______________________________________ mg/core ______________________________________ Pseudoephedrine Sulfate 120-360 Hydroxypropyl Methylcellulose 2208 160-480 100,000 cps Ethylcellulose 40-120 Dibasic Calcium Phosphate Dihydrate 56-164 Povidone 20-60 Silicon Dioxide 6-12 and Magnesium Stearate 2-6 Matrix Core Weight Range:
- 400-1200 mg ______________________________________
- and
- b. a coating on said core comprising:
- ______________________________________ mg/tablet ______________________________________ Loratadine 5-15 Hydroxypropyl Methylcellulose 2910 6 cps 17-50 Polyethylene Glycol 400 0.25-5.0 Polyethylene Glycol 3350 3.4-10.15 Approximate Coating Weight Range:
- 26-80.0 mg Approximate Composition Weight Range:
- 427-1280 mg ______________________________________
5 more elements
A film-coated extended release oral dosage composition comprising:
- a. a matrix core comprising:
- ______________________________________ mg/core ______________________________________ Pseudoephedrine Sulfate 240 Hydroxypropyl Methylcellulose 2208 100,000 cps. 160-480 Ethylcellulose 40-120 Dibasic Calcium Phosphate Dihydrate 56-164 Povidone 20-60 Silicon Dioxide 6-12 and Magnesium Stearate 2-6 Approximate Core Weight Range:
- 520-1080 mg ______________________________________
- and
- b. a coating on said core comprising:
- ______________________________________ mg/tablet ______________________________________ Loratadine 10 Hydroxypropyl Methylcellulose 2910 6 cps. 17-50 Polyethylene Glycol 400 0.25-5.0 Polyethylene Glycol 3350 3.4-10.15 Approximate Coating Weight Range:
- 31-75 mg Approximate Composition Weight Range:
- 552-1155 mg ______________________________________
5 more elements
A film-coated extended release oral dosage composition comprising:
- a. a matrix core comprising:
- ______________________________________ mg/core ______________________________________ Pseudoephedrine Sulfate USP 240 Hydroxypropyl Methylcellulose 2208 USP 100,000 cps 320 Ethylcellulose NF Type 7 80 Dibasic Calcium Phosphate USP Dihydrate 108 Povidone USP 40 Silicon Dioxide NF 8 and Magnesium Stearate NF 4 Approximate Core weight 800 mg ______________________________________
- and
- b. a coating upon said core comprising:
- ______________________________________ mg/tablet ______________________________________ Loratadine, Micronized 10 Hydroxypropyl Methylcellulose 2910 USP 6 cps 33 Polyethylene Glycol 400 NF 0.67 Polyethylene Glycol 3350 NF 6.75 Color Dispersion (Solids) 6.25 Approximate Coating Weight 57 mg Approximate Composition Weight 857 mg ______________________________________
2 more elements
Dependencies are inferred from the claim text.