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US 5,314,695 AGranted
Tissue factor based prothrombin time reagent
AssigneeCorvas International, Inc.
InventorScott M. Brown
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Abstract
Prothrombin time reagents are provided which comprise novel liposome compositions in which tissue factor is associated with an inserted into the phospholipid bilayer of the liposomes. Methods for their preparation are also provided. The liposome compositions may be adjusted to allow maximum coagulant activity and sensitivity to extrinsic coagulation factors.
Claims9
A prothrombin time reagent containing purified natural or recombinant tissue factor which comprises a liposome composition comprising:
- (a) a phospholipid mixture comprising:
- (i) from about 20 to about 95 mole percent phosphatidylcholine,
- (ii) from about 2.5 to about 50 mole percent phosphatidylethanolamine,
- (iii) from about 2.5 to about 50 mole percent phosphatidylserine, and
- (iv) from about 0 to 40 mole percent phosphatidylglycerol;
- and
- (b) from about 0.1 .mu.g to about 3 .mu.g of tissue factor per mg phospholipid mixture.
4 more elements
Dependencies are inferred from the claim text.