Polyazamacrocycles for magnetic resonance imaging
AssigneeMallinckrodt Medical, Inc.
InventorsRaghavan Rajagopalan, Rebecca A. Wallace, Muthunadar P. Periasamy
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Abstract
Novel magnetic resonance imaging agents comprise complexes of paramagnetic ions with hydrazide derivatives of polyaminocarboxylic acid chelating agents. These novel imaging agents are characterized by excellent NMR image-contrasting properties and by high solubilities in physiological solutions. A novel method of performing an NMR diagnostic procedure involves administering to a warm-blooded animal an effective amount of a complex as described above and then exposing the warm-blooded animal to an NMR imaging procedure, thereby imaging at least a portion of the body of the warm-blooded animal.
Claims33
A complex comprising the formula:
- ##STR13## wherein M.sup.z+ is a paramagnetic ion of an element with an atomic number 21-29, 42-44, or 58-70 and a valence, z, of 2+ or 3+;
- B is selected from a group consisting of ##STR14## the R.sub.6 groups are selected from a group consisting of ##STR15## wherein at least one R.sub.6 group is ##STR16## the R.sub.8, R.sub.9, and R.sub.10 groups may be the same or different selected from a group consisting of hydrogen, alkyl, acyl, aryl, mono- or poly- hydroxyalkyl, mono- or polyalkoxyalkyl, aminoalkyl and acylaminoalkyl;
- the carbon-containing R groups preferably contain 1 to 6 carbon atoms and m varies from preferably 1 to 6.
A diagnostic composition suitable for enteral or parenteral administration to a warm-blooded animal, which comprises a MRI-effective amount of a complex of a paramagnetic ion having the following formula, ##STR24## wherein M.sup.z+ is a paramagnetic ion of an element with an atomic number 21-29, 42-44, or 58-70 and a valence, z, of 2+ or 3+;
- B is selected from a group consisting of ##STR25## the R.sub.6 groups are selected from a group consisting of --O.sup.-, ##STR26## wherein at least one R.sub.6 group is ##STR27## the R.sub.8, R.sub.9 and R.sub.10 groups may be the same or different selected from a group consisting of hydrogen, alkyl, acyl, aryl, mono- or poly- hydroxyalkyl, mono- or polyalkoxyalkyl, aminoalkyl and acylaminoalkyl;
- the carbon-containing R groups preferably contain 1 to 6 carbon atoms and m varies from preferably 1 to 6.
A method of performing a MRI diagnostic procedure, which comprises administering to a warm-blooded animal an effective amount of a complex of the formula:
- ##STR32## wherein M.sup.z+ is a paramagnetic ion of an element with an atomic number 21-29, 42-44, or 58-70 and a valence, z, of 2+ or 3+;
- B is selected from the group consisting of ##STR33## the R.sub.6 groups are selected from a group consisting of --O.sup.-, ##STR34## wherein at least one R.sub.6 group is ##STR35## the R.sub.8, R.sub.9, and R.sub.10 groups may be the same or different selected from a group consisting of hydrogen, alkyl, acyl, aryl, mono- or poly- hydroxyalkyl, mono- or polyalkoxyalkyl, aminoalkyl and acylaminoalkyl;
- the carbon-containing R groups preferably contain 1 to 6 carbon atoms and m varies from preferably 1 to 6;
- and then exposing the animal to a MRI imaging procedure thereby imaging at least a portion of the body of the warm-blooded animal.
Dependencies are inferred from the claim text.