Sodium iodide .sup.131 I capsules
AssigneeMallinckrodt Medical, Inc.
InventorsGlenn D. Grummon, David E. Helling
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Abstract
The present invention relates to radiopharmaceutical products used in the treatment of thyroid diseases. In particular, the present invention relates to sodium iodide .sup.131 I capsules which have increased stability and lower volatility. The objects of the present invention are achieved by providing a .sup.131 I capsule having a matrix material and antioxidant additive combination which provides for increased stability and reduced volatility of the capsule.
Claims5
A .sup.131 I capsule having improved stability and reduced volatility, said capsule having a matrix material and a radioiodide loading solution, wherein said matrix material comprises a 10% blend ascorbic acid in anhydrous sodium pyrophosphate, and said radioiodide loading solution is made 0.25M in both sodium thiosulfate and sodium ascorbate and further includes fructose.
A .sup.131 I capsule having improved stability and reduced volatility, said capsule having a matrix material and a radioiodide loading solution, said matrix material comprising a blend of fructose with 10% gentisic acid, and said radioiodide loading solution is made 0.25M in both sodium thiosulfate and sodium ascorbate.
Dependencies are inferred from the claim text.