Interaction system comprising a surfactant-stabilized aqueous phase containing an antibody fragment
AssigneeIgen, Inc.
InventorsCharles N. Durfor, Richard J. Bolin, Allen R. Schantz, II, Richard J. Massey
Life of this patent
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Abstract
An interaction system, including an antibody or, antibody fragment having functional capability, which comprises a surfactant-stabilized microheterogeneous dispersion of aqueous phase in a water-immiscible medium, said aqueous phase containing an amount of said antibody or said fragment in a functional state sufficient to effect the interaction; and methods for making and for using said system.
Claims40
An interaction system, including an antibody or antibody fragment having functional capability, which comprises a surfactant-stabilized microheterogeneous dispersion of aqueous phase in a water-immiscible medium, said aqueous phase containing an amount of said antibody or said fragment in a functional state sufficient to effect the interaction;
- wherein said antibody or antibody fragment is adapted to effect a catalytic conversion of one or more reactants into one or more products.
In a water-immiscible medium, an interaction system including an antibody or antibody fragment having functional capability, which comprises a plurality of surfactant-stabilized microheterogeneously disperse aqueous phase particles, said particles containing an amount of said antibody or said fragment in a functional state sufficient to effect said interaction;
- wherein said antibody or antibody fragment is adapted to effect a catalytic conversion of one or more reactants into one or more products.
A system for interacting a catalytic antibody, or catalytic antibody fragment with a reactant, which comprises a surfactant-stabilized microheterogeneous dispersion of aqueous phase in a water-immiscible medium, said aqueous phase containing an amount of said catalytic antibody or catalytic antibody fragment sufficient to effect said catalysis.
In a water-immiscible medium, a system for interacting a catalytic antibody or catalytic antibody fragment with a reactant, which comprises a plurality of microheterogeneously dispersed aqueous phase particles containing an amount of said catalytic antibody or catalytic antibody fragment sufficient to effect the interaction.
A method of interacting an antibody, or antibody fragment having functional capability, with at least one species, which comprises maintaining said antibody or fragment in a plurality of surfactant-stabilized microheterogeneously dispersed aqueous phase particles, said aqueous phase particles containing an amount of said antibody or fragment in a functional state sufficient to effect said interaction, at conditions under which the antibody or fragment is accessible to said species and that are sufficient to effect said interaction for a time sufficient for said interaction to occur;
- wherein said antibody or antibody fragment is catalytic in function.
A method of converting at least one reactant to at least one product, which comprises maintaining a system comprising a surfactant-stabilized microheterogeneous dispersion of aqueous phase, said aqueous phase containing an amount of catalytic antibody or catalytic antibody fragment sufficient to effect said conversion, at conditions under which the catalytic antibody or catalytic antibody fragment is accessible to said at least one reactant, and that are sufficient to effect the interaction between said catalytic antibody or catalytic antibody fragment and said at least one reactant to form said at least one product for a time sufficient for said interaction to occur.
Dependencies are inferred from the claim text.