Crystallization method to improve crystal structure and size
AssigneeMerck & Co., Inc.
InventorsMichael Midler, Jr., Edward L. Paul, Edwin F. Whittington, Mauricio Futran, Paul D. Liu, Jaanpyng Hsu, Shih-Hsie Pan
Life of this patent
Estimating the term…
Abstract
Impinging fluid jet streams are used in a continuous crystallization process to achieve high intensity micromixing of fluids so as to form a homogeneous composition prior to the start of nucleation. This process permits direct crystallization of high surface area particles of high purity and stability.
Claims28
A process for crystallization of an organic pharmaceutical compound comprising contacting one or more jet streams of a feed solution of the organic pharmaceutical compound with one or more jet stream of an anti-solvent, said jet streams impinging to create high turbulence at their point of impact, and each jet stream having sufficient linear velocity to achieve high intensity micromixing of the feed solution and the anti-solvent prior to nucleation, followed by nucleation and the direct production of small crystals, at least 95% of said crystals having a diameter equal to or less than 25 microns.
A process for crystallization of an organic pharmaceutical compound comprising contacting one or more jet streams of a first feed solution of the organic pharmaceutical compound with one or more jet streams of a second feed solution of the organic pharmaceutical compound, said jet streams impinging to create high turbulence at their point of impact, and each jet stream having sufficient linear velocity to achieve high intensity micromixing of the first and second feed solutions prior to nucleation, followed by nucleation and the direct production of small crystals, at least 95% of said crystals having a diameter equal to or less than 25 microns.
A process for crystallization of an organic pharmaceutical compound comprising contacting two opposing jet streams, one jet stream comprising a feed solution of the organic pharmaceutical compound and the other jet stream comprising an anti-solvent, said opposing jet streams impinging to create high turbulence at their point of impact, and each jet stream having sufficient linear velocity to achieve high intensity micromixing of the feed solution and the anti-solvent prior to nucleation, followed by nucleation and the direct production of small crystals, at least 95% of said crystals having a diameter equal to or less than 25 microns.
Dependencies are inferred from the claim text.