US 5,312,986 A · Hexacarboxylic acid hexa-amides which form liphophilic complexes with magnesium ions, corresponding magnesium complexes, and test devices and ion selective parts containing such hexacarboxylic acid hexa-amides

Abstract

Hexacarboxylic acid hexa-amides are described which form new lipophilic magnesium complexes with magnesium ions. The hexa-amides are preferably novel compounds comprising three dicarboxylic acid diamide moieties interconnected to form a non-cyclic, monocyclic, bicyclic, tricyclic or polycyclic structure. Test devices such as test trips or ion-selective members are provided which contain hexacarboxylic acid hexa-amides as the ion-selective component. The test devices have a high selectivity for magnesium ions over alkali metal ions and other alkaline earth metal ions. Selectivity for magnesium ions over sodium and calcium ions permits determination of magnesium concentration in biological materials, including body fluids such as blood serum or whole blood. Magnesium concentration and activity can also be determined in sample solutions having a neutral or slightly acidic pH.

Claims8

Dependent claims

A hexacarboxylic acid hexa-amide adapted for forming lipophilic complexes with magnesium ions, and lipophilic complexes of said hexacarboxylic acid hexa-amide with magnesium ions, said hexacarboxylic acid hexa-amide having the following formula II:

##STR22## wherein (i) n, n' and n" are independently 1 or 2,
(ii) R.sub.1 and R.sub.2 are independently selected from the group A, consisting of hydrogen, C.sub.1 -C.sub.15 alkyl, C.sub.2 -C.sub.15 alkenyl, C.sub.2 -C.sub.15 alkynyl, cyclohexyl and phenyl;
(iii) R.sub.1 ' and R.sub.2 ' are independently selected from the group A defined above;
(iv) R.sub.1 " and R.sub.2 " are independently selected from group A as defined above;
(v) R.sub.3 is selected from the group B consisting of a divalent aliphatic, alicyclic and aromatic hydrocarbon radicals;
(vi) R.sub.3 " is selected from group A defined above;
(vii) R.sub.4 is selected from group B defined above;
(viii) R.sub.4 ' is selected from group A defined above;
(ix) R.sub.5, R.sub.5 ', R.sub.5 ", R.sub.6, R.sub.6 ' and R.sub.6 " are independently selected from the group consisting of hydrogen, C.sub.1 -C.sub.4 alkyl and halogen.

6 more elements

(ii) R.sub.1, R.sub.1 ', R.sub.3 and R.sub.3 " are independently selected from the group A consisting of hydrogen, C.sub.1 -C.sub.15 alkyl, C.sub.2 -C.sub.15 alkenyl, C.sub.2 -C.sub.15 alkynyl, and cyclohexyl and phenyl;
(iii) R.sub.2 and R.sub.4 are independently selected from the group B consisting of divalent, aliphatic, alicyclic and aromatic hydrocarbon radicals,
(iv) R.sub.1 " and R.sub.2 " are independently selected from the group A as defined above;
(v) R.sub.3 ' and R.sub.4 ' are independently selected from group A defined above;
and
(vi) R.sub.5, R.sub.5 ', R.sub.5 ", R.sub.6, R.sub.6 ' and R.sub.6 " are independently selected from the group consisting of hydrogen, C.sub.1 -C.sub.4 alkyl and halogen.

3 more elements

Dependencies are inferred from the claim text.

Hexacarboxylic acid hexa-amides which form liphophilic complexes with magnesium ions, corresponding magnesium complexes, and test devices and ion selective parts containing such hexacarboxylic acid hexa-amides

Life of this patent

Hexacarboxylic acid hexa-amides which form liphophilic complexes with magnesium ions, corresponding magnesium complexes, and test devices and ion selective parts containing such hexacarboxylic acid hexa-amides

Life of this patent

Abstract

Claims8