Method of synthesizing the precursor pyruvamide
AssigneeAbbott Laboratories
InventorsMadhup K. Dhaon, John A. Houbion
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Abstract
A method for administering pyruvate is disclosed which comprises administering a therapeutically effective amount of a pyruvate precursor to a mammal in the form of pyruvamide or a pyruvyl-amino acid. The pyruvyl-amino acid is preferably selected from the group comprising pyruvyl-glycine, pyruvyl-alanine, pyruvyl-leucine, pyruvyl-valine, pyruvyl-isoleucine, pyruvyl-phenylalanine, pyruvyl-proline and pyruvyl-sarcosine, and their amides and esters as well as their salts. Associated with the administration of a pyruvate precursor to a mammal in accordance with this invention are improved insulin resistance, lower fasting insulin levels, and reduced fat gain. Novel methods of synthesizing several pyruvate precursors are also disclosed.
Claims2
A method of synthesizing the pyruvate precursor pyruvamide comprising the steps of:
- (a) reacting sodium pyruvate with a substance selected from the group consisting of thionyl chloride and oxalyl chloride to yield pyruvyl chloride;
- and
- (b) reacting the pyruvyl chloride with 1,1,1,3,3,3-hexamethyldisilazane at a temperature of 0.degree.-40.degree. Centrigrade, followed by treatment with methanol in the presence of a solvent to generate pyruvamide.
Dependencies are inferred from the claim text.