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US 5,312,958 AGranted
Process for producing 4-bromomethylbiphenyl compounds
AssigneeTakeda Chemical Industries, Ltd.
InventorsSyuji Suenaga, Hitoshi Kawaguchi, Takeshi Kato
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Abstract
A process for the production of a compound of general formula ##STR1## wherein R represents cyano, carboxy which may be esterified or amidated or tetrazolyl which may be substituted, comprising brominating the corresponding methyl compound with a brominating agent such as N -bromoacetamide, N-bromophtalimide, N-bromosuccinimide and so on in a halogenated hydrocarbon solvent in the presence of an azobis compound.
Claims4
A process for producing a 4-bromomethylbiphenyl compound of the formula:
- ##STR5## wherein R represents cyano, carboxy, carbamoyl or tetrazolyl which may be substituted with a straight-chain or branched C.sub.1-6 alkyl group which may be substituted with 1 to 3 phenyl groups, which comprises brominating a compound of the formula:
- ##STR6## Wherein R is as defined above, with a brominating agent selected from the group consisting of N-bromoacetamide, N-bromophthalimide, N-bromosuccinimide, N-bromomaleimide and N-bromosulfonamide, in the presence of an azobis compound represented by the formula:
- ##STR7## wherein R.sup.4 and R.sup.5 independently represent hydrogen or a straight-chain or branched lower C.sub.1-6 alkyl group optionally substituted with hydroxy, amino, imino, halogen or a lower C.sub.1-4 alkoxy group;
- R.sup.4 may be taken together with R.sup.5 to form a ring, in a methylene chloride solvent.
1 more element
Dependencies are inferred from the claim text.