Back to results
US 5,312,957 AGranted
Enantioselective hydrocyanation of aromatic vinyl compounds
AssigneeE. I. Du Pont de Nemours and Company
InventorsAlbert L. Casalnuovo, Thaliyil V. Rajanbabu, Lawrence W. Gosser, Ronald J. McKinney, Nugent, Jr. William A.
Life of this patent
Estimating the term…
Abstract
The invention provides a process for enantioselective hydrocyanation of aromatic vinyl compounds which produces nonracemic mixtures of chiral, arylpropionitriles; novel carbohydrate phosphorus and nickel catalyst compositions; and optically pure (S)-(-)-2-(6-methoxy-2-naphthalene)propionitrile.
Claims2
A product of the process of enantioselective hydrocyanation, comprising:
- reacting an aromatic vinyl compound with a source of HCN;
- in the presence of a catalyst composition comprising zero-valent nickel and a chiral, nonracemic, bidentate organophosphorus ligand of the formula (R.sup.1).sub.2 --P--R.sup.2 --P--(R.sup.1).sub.2
- to produce a nonracemic nitrile product;
- wherein the aromatic vinyl compound is 6-methoxy-2-vinylnaphthalene, each R.sup.1 is 3,5-bis(trifluoromethyl)phenyl;
- and R.sup.2 is di-O-substituted glucose of the formula ##STR35##
2 more elements
Optionally pure (S)-(-)-2-(6-methoxy-2-naphthalene)propionitrile.
Dependencies are inferred from the claim text.