Bis- and tetrakis-phosphonates useful for treating calcium related disorders
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsEli Breuer, Gershon Golomb
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Abstract
Novel bisphosphonates comprise compounds of the formula (I) ##STR1## wherein m and l are independently 1 or 2; R.sub.1 represents hydrogen, a lower alkyl group, or an alkali metal cation; R.sub.2 represents hydrogen, a lower alkyl group or an alkali metal cation; Y represents .dbd.0 or .dbd.N--OH, or --OH and X represents --(CH.sub.2).sub.n --, a branched alkylene group, or a branched or straight alkenylene or alkynylene chain optionally substituted by one or more oxygen or nitrogen atoms, wherein n is an integer from 3 to 24. Further definitions of X are included in the description.
Claims4
Disodium dihydrogen isophthaloylbisphosphonate.
Octamethyl 1,12-dihydroxydodecane-1,1,12,12-tetrakisphosphonate.
A Bis- or Tetraskis-phosphonate compound of the formula (I) ##STR11## wherein m and l are independently 1 or 2;
- R.sub.1 represents hydrogen, a lower alkyl group, or an alkali metal cation;
- R.sub.2 represents hydrogen, a lower alkyl group or an alkali metal cation;
- Y represents .dbd.O or .dbd.N--OH, or --OH;
- and X is --CH.sub.2 --A--CH.sub.2 -- in which A represents an aromatic group selected from the group consisting of phenylene, naphthalenediyl, thiophenediyl or furandiyl.
A Bis- or Tetrakis-phosphonate compound of the formula (I) ##STR12## wherein m and l are independently 1 or 2;
- R.sub.1 represents hydrogen, a lower alkyl group, or an alkali metal cation;
- R.sub.2 represents hydrogen, a lower alkyl group or an alkali metal cation;
- Y represents .dbd.O or .dbd.N--OH, or --OH;
- and X is --B--A--B-- wherein B represents a branched group or straight alkylene, or an alkenylene or alkynylene chain optionally substituted by one or more oxygen or nitrogen atom, and A represents phenylene.
Dependencies are inferred from the claim text.