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US 5,312,944 AGranted
Antibacterial silane coupler compounds containing guanidyl group
AssigneeMitsubishi Material Corporation
InventorsTsunetoshi Honda, Akiko Azuma, Akira Nishihara
Life of this patent
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Abstract
Novel silane coupler compounds having antibacterial activity are disclosed. Biguanidyl group or cyanoguanidyl group is introduced into silane coupler compounds.
Claims3
Silane coupler compounds represented by the formula (I):
- XSi(CH.sub.2).sub.n (NH(CH.sub.2).sub.2).sub.m G
- wherein X is a halogen or a C1-C5 alkoxy group, n is an integer of 1-6, m is an integer of 0 or 1 and G is a cyanoguanidyl or biguanidyl group, which may be substituted with a C1-C8 alkyl, a phenyl, which may be substituted with halogen, a C1-C4 alkyl or fluoromethyl, or a salt thereof.
Process for preparation of the compounds of formula (I),
- XSi(CH.sub.2).sub.n (NH(CH.sub.2).sub.2).sub.m G
- wherein X is a halogen or a C1-C5 alkoxy group, n is an integer of 1-6, m is an integer of 0 or 1 and G is a cyanoguanidyl, comprising reacting a compound of formula (II):
- XSi(CH.sub.2).sub.n (NH(CH.sub.2).sub.2).sub.m NH.sub.2
- with a compound of formula:
- NC--N.dbd.C(SCH.sub.3)NH.sub.2
- or
- NaN(CN).sub.2.
4 more elements
Process for preparation of the compounds of the formula (I):
- XSi(CH.sub.2).sub.n (NH(CH.sub.2).sub.2).sub.m G
- wherein X is a halogen or a C1-C5 alkoxy group, n is an integer of 1-6, m is an integer of 0 or 1 and G is a biguanidyl group, which may be substituted with a C1-C8 alkyl, a phenyl, which may be substituted with halogen, a C1-C4 alkyl or fluoromethyl, or a salt thereof, comprising reacting a compound of formula (I):
- XSi(CH.sub.2).sub.n (NH(CH.sub.2).sub.2).sub.m G
- wherein G is a cyanoguanidyl, with an amine compound of formula:
- ZNH.sub.2
- wherein Z is hydrogen, C1-C20 alkyl or phenyl, which may be substituted with halogen, alkyl, fluoroalkyl or alkoxy.
3 more elements
Dependencies are inferred from the claim text.