Method for preparing substituted nitrogen-heterocyclic compounds
AssigneeGeneral Electric Company
InventorsJohn C. Schmidhauser, Kathryn L. Longley, William L. Gately
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Abstract
Halo-displacement reaction products of aliphatic hydroxy compounds and chloro- or bromo-substituted aromatic nitrogen-heterocyclic compounds are conducted under alkaline conditions in the presence of a phase transfer catalyst, in the substantial absence of water inorganic salts other than those formed in the reaction. The method is particularly useful for the preparation of substituted chlorotriazines. In a preferred embodiment, the reagents constitute at least about 25% by weight of the organic phase of the reaction mixture.
Claims18
A method for preparing a halo-displacement reaction product of (A) an aliphatic hydroxy compound and (B) an alkoxy- or aryloxy-substituted dichloro-1,3,5-triazine, which comprises effecting contact between reagents A and B in solution in a substantially water-immiscible organic solvent under alkaline conditions, in the presence of a phase transfer catalyst and in the substantial absence of inorganic salts other than those formed in the reaction;
- reagent A being employed in the amount of at most 30% in excess of stoichiometric.
Dependencies are inferred from the claim text.