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US 5,312,904 AGranted
Cationic complexes of technetium-99M
AssigneeAmersham International plc
InventorsJames D. Kelly, Kwok W. Chiu, David V. Griffiths, Jonathan R. Dilworth
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Abstract
Tridentate mono-anionic ligands have the structure X-A-Y-Q-Z where each of X and Y is independently P, As or N, Z is phenol, thiophenol or thiol, and A and Q are hydrocarbon linking groups. The ligands from cationic complexes with Technetium-99m, e.g. [Tc.sup.III K.sub.2 ].sup.+ where K is the ligand, having useful imaging properties.
Claims7
A complex with technetium having the formula [.sup.99m Tc.sup.III K.sub.2 ].sup.+ where K is a tridentate mono-anionic ligand having the structure
- R.sub.2 X-A-YR-Q-Z
- where
- X is P, As or N,
- Y is P, As or N, wherein at least one of X and Y is P or As,
- Z is phenolic OH, thiophenol or thiol,
- each of A and Q is a C1-C4 hydrocarbon bridge, two adjacent C atoms of which may form part of a benzene ring and which may carry at least one C1-C4 alkyl, alkoxy alkyl, alkoxy or tetrahydropyran substituent,
- R is the same or different at different places in the molecule, and in each case is selected from the group consisting of C1 to C4 alkyl, alkoxy, alkoxyalkyl and alkoxyalkoxy alkyl.
4 more elements
Dependencies are inferred from the claim text.