Lysine-glycosylated recombinant interleukin-2
AssigneeE. I. Du Pont de Nemours and Company
InventorsTimo J. Linna, Subramaniam Sabesan
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Abstract
This invention relates to chemical modification of biologically active proteins which alters the chemical, physical and biological properties of the proteins. More specifically, this invention relates to the additions of various carbohydrate moieties by chemical means to bacterially produced recombinant interleukin-2 molecules.
Claims6
A composition of matter comprising a lysine glycosylated rIL-21 wherein a carbohydrate-tether conjugate is covalently linked to an amino group of at least one lysine of the rIL-2 and wherein said lysine glycosylated rIL-2 demonstrates reduced T-cell stimulating activity as compared with unglycosylated rIL-2.
Dependencies are inferred from the claim text.