Compounds and method for protection of cells and tissues from irreversible injury due to lactic acidosis
AssigneeThe Regents of the University of California
InventorTsutomu Nakada
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Abstract
Compounds and a method useful for protection of tissue cells in a mammalian body from irreversible damages due to lactic acidosis caused by oxygen deficiency. The protection is achieved by administering a compound having a cell membrane permeability and/or ability to cross the blood brain barrier and being able to provide a buffering action to prevent an increase in a hydrogen ion concentration over the physiologically acceptable levels.
Claims8
A method for protection of tissue cells from irreversible damages due to lactic acidosis caused by oxygen deficiency which method comprises administration to a patient in need of such treatment of a compound permeable through a cell membrane, or crossing the blood-brain barrier, which compound is able to buffer an increase in hydrogen ion concentration in the cells to the physiologically acceptable levels, wherein said compound is NH.sub.2 CH.sub.2 CH.sub.2 SO.sub.3 H, NH.sub.2 --C(NH)NH(CH.sub.2).sub.2 SO.sub.3 H, or NH.sub.2 --C(NH)NH(CH.sub.2).sub.2 SO.sub.3 Na.
Dependencies are inferred from the claim text.