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US 5,312,837 AGranted
Method of treating viral infections with aryl macrocyclic compounds
AssigneeGenelabs Technologies, Inc.
InventorsKou M. Hwang, You M. Qi, Su-Ying Liu
Life of this patent
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Abstract
A method for inhibiting cell infection by an enveloped virus, by administering to an infection site, a therapeutically effective amount of a macrocyclic compound composed of aryl ring subunits connected one to another by ring-attached bridge linkages, and containing sulfonic acid-derived substituents carried on non-bridge atoms of the subunits.
Claims8
A method of inhibiting cell infection by a herpesvirus comprising
- administering to the site of infection a therapeutically effective dose of a macrocyclic compound which has the form ##STR3## where R.sub.2 is a sulfonic acid, sulfonate salt, sulfinic acid, sulfinate salt, alkyl sulfonate, alkyl sulfinate, or a sulfonamide, R.sub.1 is OH, .dbd.O, an alkyl or aryl ether, ester, or acid, or a mixture thereof, R.sub.4 is >CHR" or .gtoreq.CR", where R" is H or a carboxylic acid group, and n=4, 6, or 8.
Dependencies are inferred from the claim text.