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US 5,312,733 AGranted
Developmental marker gene of CD4-CD8 thymocytes
AssigneeResearch Development Foundation
InventorCarol L. MacLeod
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AssigneeResearch Development Foundation
InventorCarol L. MacLeod
Estimating the term…
The present invention provides novel DNA sequences, recombinant DNA (rDNA) molecules, processes for producing novel T-cell proteins expressed in T-cell development, the novel T-cell proteins in substantially pure form and antibodies which bind to the novel proteins. More particularly, it relates to novel DNA sequences expressed in appropriate hosts and the novel T-cell proteins produced in these hosts. The present invention also provides novel transmembrane proteins in substantially pure form, rDNA molecules encoding transmembrane proteins and processes for producing the novel transmembrane proteins. The DNA sequences and recombinant DNA molecules of this invention are characterized in that they are expressed by T lymphoma cells and have at least one of the following characteristics: (1) is expressed in normal thymus, activated spleen cells, or gut associated lymphoid tissue, (2) is expressed in ovarian tissue, normal liver and/or in a stage specific manner in embryonic development and (3) encode novel transmembrane proteins having multiple membrane spanning domains.
An expression vehicle which comprises a DNA sequence of a gene selected from the group consisting of 19.1 (seq. id. No. 1), 19.2 (seq. id. no. 2), 19.4 (seq. id. no. 3), 19.5 (seq. id. no. 4) and 20.5 (seq. id. no. 5) wherein said expression vehicle is capable of replication in a host which comprises, in operable linkage:
A vector comprising a DNA sequence coding for a T lymphoma cell protein, wherein said T cell protein is encoded by a gene selected from the group consisting of 19.1 (seq. id. no. 1), 19.2 (seq. id. no. 2) 19.4 (seq. id. no. 3), 19.5 (seq. id. no. 4), and 20.5 (seq. id. 5) and said vector is capable of replication in a host which comprises, in operable linkage:
A host transformed with a recombinant DNA molecule, wherein said recombinant DNA molecule comprises a DNA sequence for a gene selected from the group consisting of 19.1 (seq. id. no. 1), 19.2 (seq. id. no. 2), 19.4 (seq. id. no. 3), 19.5 (seq. id. no. 4) and 20.5 (seq. id. no. 5).
The host of claim 20, which is E. coli.
Dependencies are inferred from the claim text.