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US 5,312,620 AGranted
Polymeric immunological adjuvants
OwnerHans O. Ribiinventor
Life of this patent
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Abstract
Adjuvants for enhancing the immune response to an antigen are provided comprising the adjuvant incorporated into a lipid layer where the adjuvant is covalently or non-covalently involved in a polymeric system. Conveniently, the adjuvant may be conjugated to a polymerizable group and co-polymerized with a water-soluble and/or amphiphilic polymerizable monomer or combined with a polymerized amphiphile. The adjuvant and antigen may then be administered to a mammalian host to obtain enhanced immune response.
Claims4
A polymeric immunological adjuvant composition comprising:
- a copolymer comprising at least one adjuvant joined to a water soluble addition polymerizable acrylyl or methacrylyl monomer through a linking group and a lamellar forming lipid comprising a chain of from 8 to not more than 36 carbon atoms and joined to a water soluble addition polymerizable acrylyl or methacrylyl monomer;
- said lipid adjuvant selected from the group consisting of monophosphoryl lipid A, lipopolysaccharide, BCG cell wall skeleton, diphosphoryl lipid A, muramyl di- or tripeptide, muramyl dipeptide-phosphatidyl-ethanolamine, muramyltripeptide phosphatidylethanolamine, trehalose monomycolate, trehalose dimycolate, lipid X, isoprinosine, and lithosperman (A, B or C).
Dependencies are inferred from the claim text.