Liposoluble compounds useful as magnetic resonance imaging agents
OwnerEvan C. Unger, DeKang Sheninventors
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Abstract
Novel complexes of paramagnetic ions and compounds bearing long acyl chains have been synthesized as magnetic resonance imaging contrast agents. These novel liposoluble contrast agents may be administered alone, or with lipids, suspending agents or other additives. The lipids may be in the form of liposomes, micelles or lipid emulsions. The contrast agents of the invention have particular use in magnetic resonance imaging of the liver, blood pool and reticuloendothelial system.
Claims18
A method of providing an image of an internal region of a patient comprising (i) administering to the patient a contrast agent comprising a paramagnetic ion in combination with a compound of the formula, ##STR20## wherein:
- R.sub.1 and R.sub.2 are, independently, H, or a substituted or unsubstituted C.sub.7 -C.sub.10 straight chain or cyclic compound;
- each R.sub.3 and R.sub.4 are, independently, H, or a substituted or unsubstituted C.sub.1 -C.sub.30 straight chain or cyclic compound;
- and
- A is N, or a N-containing substituted or unsubstituted C.sub.1 -C.sub.30 straight chain or cyclic compound;
- z is 1 to 10;
- provided that at least one of R.sub.1 and R.sub.2 is other than H, and at least one of R.sub.3 and R.sub.4 is other than H;
- and
- (ii) scanning the patient using magnetic resonance imaging to obtain visible images of the region.
A method for diagnosing the presence of diseased tissue in a patient comprising (i) administering to the patient a contrast agent comprising a paramagnetic ion in combination with a compound of the formula, ##STR21## wherein:
- R.sub.1 and R.sub.2 are, independently, H, or a substituted or unsubstituted C.sub.7 -C.sub.30 straight chain or cyclic compound;
- each R.sub.3 and R.sub.4 are, independently, H, or a substituted or unsubstituted C.sub.1 -C.sub.30 straight chain or cyclic compound;
- and
- A is N, or a N-containing substituted or unsubstituted C.sub.1 -C.sub.30 straight chain or cyclic compound;
- z is 1 to 10;
- provided that at least one of R.sub.1 and R.sub.2 is other than H, and at least one of R.sub.3 and R.sub.4 is other than H;
- and
- (ii) scanning the patient using magnetic resonance imaging to obtain visible images of any diseased tissue in the patient.
A method of providing an image of an internal region of a patient comprising (i) administering to the patient a contrast agent comprising a paramagnetic ion in combination with a compound of the formula, ##STR22## wherein:
- each R.sub.1 is, independently, a substituted or unsubstituted C.sub.7 -C.sub.30 straight chain or cyclic compound;
- each R.sub.2 is, independently, a substituted or unsubstituted C.sub.1 -C.sub.30 straight chain or cyclic compound;
- R.sub.3 is a substituted or unsubstituted C.sub.1 -C.sub.30 straight chain or cyclic compound;
- and
- each m is, independently, 0 to 12;
- and
- (ii) scanning the patient using magnetic resonance imaging to obtain visible images of the region.
A method for diagnosing the presence of diseased tissue in a patient comprising (i) administering to the patient a contrast agent comprising a paramagnetic ion in combination with a compound of the formula, ##STR23## wherein:
- each R.sub.1 is, independently, a substituted or unsubstituted C.sub.7 -C.sub.3 straight chain or cyclic compound;
- each R.sub.2 is, independently, a substituted or unsubstituted C.sub.1 -C.sub.30 straight chain or cyclic compound;
- R.sub.3 is a substituted or unsubstituted C.sub.1 -C.sub.30 straight chain or cyclic compound;
- and
- each m is, independently, 0 to 12;
- and
- (ii) scanning the patient using magnetic resonance imaging to obtain visible images of any diseased tissue in the patient.
Dependencies are inferred from the claim text.