Injectable opacifying composition containing liposomes of high encapsulation capacity for X-ray examinations
AssigneeBracco Industria Chimica S.p.A.
InventorsMichel Schneider, Herve Tournier, Bernard Lamy
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Abstract
Injectable aqueous composition intended for opacifying certain organs with a view to examination by X-rays. This composition is based on liposomes containing, encapsulated therein, an aqueous solution of an iodinated opacifying agent. The ratio between the weight of iodine encapsulated by the liposomes and the weight of the lipids from which their membrane is formed is not lower than 1.5 mg/mg.
Claims7
Process for increasing the encapsulation capacity of an aqueous suspension of liposomes comprising lipidic membrane vesicles containing, in encapsulated form, at least one opacifying agent to X-rays in solution in an aqueous liquid, wherein these liposomes in suspension in the said aqueous liquid are subjected to an extrusion through a filtering membrane with porosities ranging between 0.4 and 3 .mu.m, so as to "normalize" the size of the said vesicles in a range of values corresponding to the size of the pores of the said membrane.
Dependencies are inferred from the claim text.