Neomorphic ibuprofen
AssigneeAffinity Biotech, Inc.
InventorsRobert P. Geyer, Vinod V. Tuliani
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Abstract
A novel neomorphic form of ibuprofen and processes for preparing the ibuprofen are provided. The neomorphic form is characterized by having a distinctively less bitter taste and causes less burning sensation upon swallowing. The neomorphic form of ibuprofen is an amorphous ibuprofen and is prepared by imparting kinetic energy to supercooled ibuprofen.
Claims25
A bland tasting neomorphic form of ibuprofen comprising amorphous ibuprofen.
A process for preparing neomorphic ibuprofen having a bland taste and an amorphous structure, comprising:
- (a) providing molten ibuprofen in a supercooled state;
- (b) imparting kinetic energy into the supercooled ibuprofen for a time and intensity sufficient to convert a portion of the supercooled ibuprofen into solid amorphous ibuprofen;
- and
- (c) recovering the solid amorphous ibuprofen.
A process for preparing neomorphic ibuprofen having a bland taste and an amorphous structure, comprising:
- (a) providing a dispersion of molten ibuprofen in a supercooled state in a dispersing fluid;
- (b) imparting kinetic energy into the dispersion for a time and intensity sufficient to convert a portion of the supercooled ibuprofen into solid amorphous ibuprofen;
- and
- (c) recovering the solid amorphous ibuprofen.
Dependencies are inferred from the claim text.