Low temperature process for preparing neomorphic ibuprofen
AssigneeAffinity Biotech, Inc.
InventorsRobert P. Geyer, Vinod V. Tuliani
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Abstract
A novel neomorphic form of ibuprofen and processes for its preparation are provided. The neomorphic ibuprofen is characterized by having a distinctively less bitter and acidic taste commonly associated with conventional ibuprofen and which causes less burning sensation upon swallowing. The neomorphic form of ibuprofen is an amorphous ibuprofen and is prepared by resolidifying supercooled ibuprofen at a process temperature below 0.degree. C.
Claims16
A process for preparing neomorphic ibuprofen having a bland taste and an amorphous structure, comprising:
- (a) providing molten ibuprofen in a supercooled state at a process temperature below 0.degree. C.;
- (b) resolidifying the supercooled ibuprofen into a solid amorphous ibuprofen;
- and
- (c) recovering the solid amorphous ibuprofen.
A process for preparing neomorphic ibuprofen having a bland taste and an amorphous structure, comprising:
- (a) providing molten ibuprofen in a supercooled state at a process temperature of below about -10.degree. C.;
- (b) resolidifying the supercooled ibuprofen into a solid amorphous ibuprofen, wherein at least about 50 percent by weight of the supercooled ibuprofen is solidified into said amorphous ibuprofen;
- and
- (c) recovering the solid amorphous ibuprofen.
Dependencies are inferred from the claim text.