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US 5,310,958 AGranted
Lysolecithin derivatives
AssigneesYutaka Mizushima, Asahi Glass Company, Limited, Seikagaku Corporation
InventorYutaka Mizushima
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Abstract
A modified biologically active protein consisting essentially of a biologically active protein bonded to lecithin via a covalent linking group and a pharmaceutical composition comprising the modified biologically active protein in a pharmaceutically acceptable carrier. The biologically active proteins include antibodies, superoxide dismutase, insulin and callidinogenase. Lecithin derivatives are also disclosed.
Claims1
A lecithin derivative of the formula (V):
- ##STR6## wherein B is a residue of lysolecithin having a hydroxyl group at the 2-position of glycerol, with the hydrogen atom of the hydroxyl group removed, R.sup.3 is --R.sup.2 --C(O)NH--R.sup.1 or a sulfur-containing group wherein R.sup.1 and R.sup.2 are C.sub.1 -C.sub.24 alkylene groups and Z is a carboxyl group, a protected carboxyl group, or a carbonyl group having an ester active group bonded thereto.
Dependencies are inferred from the claim text.