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US 5,310,953 AGranted
Substituted pentaalkylchromans
AssigneesLonza Ltd., Sankyo Company, Limited
InventorDavid Laffan
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Abstract
The substituted pentaalkylchromans of the general formula: ##STR1## wherein R denotes a lower alkyl group having 1 to 4 C atoms and Hal denotes chlorine, bromine or iodine, are novel intermediates for the preparation of hypolipidaemic pharmaceuticals. A process for their preparation is described in which a trialkylhydroquinone is reacted with a halogenated butenol to give a substituted tetraalkylhydroquinone, which is finally cyclized to the final product.
Claims11
A process for the preparation of a substituted pentaalkylchroman of the formula:
- ##STR12## wherein R denotes a lower alkyl group having 1 to 4 C atoms and Hal denotes chlorine, bromine or iodine, which comprises reacting a trialkylhydroquinone of the formula:
- ##STR13## wherein R has the above-stated meaning, with a halogenated butenol of the formula:
- ##STR14## wherein Hal has the above-stated meaning, in the presence of a Lewis acid, to produce a tetraaklylhydroquinone of the formula:
- ##STR15## wherein R and Hal have the above-stated meaning, and cyclizing the tetraalkylhydroquinone in the presence of a strong acid to give the final product.
1 more element
Dependencies are inferred from the claim text.