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US 5,310,935 AGranted
Optically active 5-oxygenated (3S)-1,3-dimethyloxindole-3-acetic acids
AssigneePharmagroup International
InventorsArnold Brossi, Danilo C. Massari, Qian-Sheng Yu
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Abstract
The synthesis of optically active 5-oxygenated (3S)-1,3-dimethyloxindole-3-acetic acids ##STR1## and their use in the synthesis of optically active (3aS-cis)-eseroline and (3aS-cis)-N.sup.1 -benzylnoreseroline, which are important intermediates in the synthesis of compounds related to (3aS-cis)-physostigmine and carbamate analogs, and of (3aS-cis)-N.sup.1 -benzylnor- and N.sup.1 -norphysostigmine and their carbamate analogs.
Claims4
An optically pure (35) configured compound of the formula ##STR4## wherein R is CH.sub.3, C.sub.2 H.sub.5 or CH.sub.2 -Ph.
Dependencies are inferred from the claim text.