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US 5,310,930 AGranted
Benzofuranylimidazole derivatives, a process for their preparation and therapeutical compositions containing the same
AssigneeSociete de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
InventorsJesus A. G. Sevilla, Jose J. M. Martinez, Fernando B. Fernandez, Fernando A. G. Caballero, Angel M. Banos, Rosendo O. Vidal, Francesc P. Rodas
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Abstract
The invention relates to benzofuranylimidazole derivatives of the general formula (1) ##STR1## wherein R.sub.1 and R.sub.2 represent various radicals, to a process for their preparation and to pharmaceutical compositions containing them.
Claims6
Process for the preparation of benzofuranylimidazole derivatives of the formula ( 1) ##STR9## wherein R.sub.1 represents a hydrogen atom, and
- R.sub.2 represents a hydrogen atom, a halogen atom, an alkyl group having from 1 to 6 carbon atoms or an alkoxy group having from 1 to 5 carbon atoms;
- or a therapeutically acceptable salt of such a derivative, the process comprising the following successive steps:
- reacting a compound of formula (2) ##STR10## wherein R represents an alkyl group having from 1 to 4 carbon atoms and HX represents an acid, with, at least, one molar equivalent of an aminoacetaldehyde dialkyl acetal, in a polar solvent, for 1 to 24 hours, at a temperature of from -5.degree. C. to the boiling point of the reaction mixture thereby obtaining a compound of the formula (3) ##STR11## wherein R' and R" represent, each, an alkyl group having from 1 to 4 carbon atoms, and
- cyclizing, in an aqueous acidic medium, for 1 to 24 hours, at a temperature of from 15.degree. to 80.degree. C., the compound of the formula (3), said cyclizing resulting in compounds of the formula (1).
1 more element
Dependencies are inferred from the claim text.