Glycosaminoglycan-modified protein
AssigneeSeikagaku Corporation
InventorsKatsukiyo Sakurai, Kyosuke Miyazaki
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Abstract
A glycosaminoglycan-modified protein wherein an amino group of a protein is bound to an aldehyde group, which has been formed by reducing and partially oxidizing the reducing terminal sugar moiety of a glycosaminoglycan, which has a high stability in vivo and can retain physiological activity of the protein for a prolonged period of time.
Claims7
A glycosaminoglycan-modified protein represented by the formula:
- ##STR13## wherein P represents a protein residue exclusive of n amino groups from the protein;
- n is an integer of from 1 to 100;
- and GAG represents a glycosaminoglycan residue exclusive of a reducing terminal sugar moiety from the glycosaminoglycan.
A glycosaminoglycan-modified protein wherein a reducing terminal sugar moiety of the glycosaminoglycan is cleaved and a functional group of the reducing terminal sugar moiety-cleaved glycosaminoglycan is bound to an amino group of a protein via a covalent bond.
A glycosaminoglycan-modified protein wherein an amino group of a protein is bound to a carbonyl group of the glycosaminoglycan, which has been formed by oxidizing a reducing terminal sugar moiety of a glycosaminoglycan and treating the reducing terminal sugar moiety-oxidized glycosaminoglycan with an acid.
Dependencies are inferred from the claim text.