Aryloxyphenylpropylamines and their calcium overload blocking compositions and methods of use

A compound of formula I ##STR10## wherein X is H, cyano, halogen, C.sub.1.noteq.6 -alkoxy or C.sub.3-5 -alkylene;

• R is phenyl which is substituted with trifluoromethyl;
• and
• R.sup.1 is C.sub.1-10 -alkyl which is optionally substituted with C.sub.1-5 -alkoxy or cyano;
• and
• R.sup.2 is C.sub.3-7 -cycloalkyl, C.sub.2-10 -alkenyl or -C.sub.1-5 -alkyl-C.sub.3-6 -cycloalkyl which is optionally substituted with C.sub.1-5 -alkoxy or cyano;
• or a pharmaceutically acceptable salt thereof.

A compound of formula I ##STR11## wherein X is cyano, halogen, C.sub.1-6 -alkoxy or C.sub.3-5 -alkylene;

• R is phenyl which is substituted with trifluoromethyl;
• and
• R.sup.1 and R.sup.2 independently are C.sub.1-10 -alkyl, C.sub.3-7 -cycloalkyl, C.sub.2-10 -alkenyl or -C.sub.1-5 -alkyl-C.sub.3-6 -cycloalkyl which are optionally substituted with C.sub.1-5 -alkoxy or cyano;
• or a pharmaceutically acceptable salt thereof.

A compound of formula I ##STR12## wherein X is H, cyano, halogen, C.sub.1-6 -alkoxy, C.sub.1-6 -alkyl or C.sub.3-5 -alkylene;

• R is phenyl which is substituted with C.sub.3 - or C.sub.5 -alkylene;
• and
• R.sup.1 and R.sup.2 independently are C.sub.1-10 -alkyl, C.sub.3-7 -cycloalkyl, C.sub.2-10 -alkenyl or -C.sub.1-5 -alkyl-C.sub.3-6 -cycloalkyl which are optionally substituted with C.sub.1-5 -alkoxy or cyano;
• provided that R.sup.1 is not C.sub.3-7 -cycloalkyl, C.sub.1-10 -alkyl or C.sub.2-10 -alkenyl which are optionally substituted with C.sub.1-4 -alkoxy, when X is H and R.sup.2 is a methyl group;
• or a pharmaceutically acceptable salt thereof.

A compound of formula I ##STR13## wherein X is H, cyano, halogen, C.sub.1-6 -alkoxy, C.sub.1-6 -alkyl or C.sub.3-5 -alkylene;

• R is phenyl which is substituted with C.sub.4 -alkylene;
• and
• R.sup.1 and r.sup.2 independently are C.sub.1-10 -alkyl, C.sub.3-7 -cycloalkyl, C.sub.2-10 -alkenyl or -C.sub.1-5 -alkyl-C.sub.3-6 -cycloalkyl which are optionally substituted with C.sub.1-5 -alkoxy or cyano;
• provided that R.sup.1 is not C.sub.3-7 -cycloalkyl, C.sub.1-10 -alkyl or C.sub.2-10 -alkenyl which are optionally substituted with C.sub.1-4 -alkoxy, when X is H and R.sup.2 is a methyl group;
• or a pharmaceutically acceptable salt thereof.

A compound of formula I ##STR14## wherein X is H, cyano, halogen, C.sub.1-6 -alkoxy, C.sub.1-6 -alkyl or C.sub.3-5 -alkylene;

• R is 3,4-methylenedioxyphenyl which is optionally substituted with cyano, halogen, C.sub.1-6 -alkyl, C.sub.1-6 -alkoxy, C.sub.2-6 -alkenyl, trifluoromethyl or C.sub.3-5 -alkylene;
• and
• R.sup.1 and R.sup.2 independently are C.sub.1-10 -alkyl, C.sub.3-7 -cycloalkyl, C.sub.2-10 -alkenyl or -C.sub.1-5 -alkyl-C.sub.3-6 -cycloalkyl which are optionally substituted with C.sub.1-5 -alkoxy or cyano;
• provided that R.sup.1 is not C.sub.3-7 -cycloalkyl, C.sub.1-10 -alkyl or C.sub.2-10 -alkenyl which are optionally substituted with C.sub.1-4 -alkoxy, when X is H and R.sup.2 is a methyl group;
• or a pharmaceutically acceptable salt thereof.